Dear Colleagues,
We are pleased to announce the winners of the Antioxidants 2020 Outstanding Reviewer Awards. The Antioxidants Editorial Board and Editorial Team gratefully acknowledge the time and energy dedicated by reviewers in checking the manuscripts submitted to Antioxidants. It is due to their efforts that the high quality of the journal and quick turnaround have been maintained.
Two Outstanding Awards for Excellence in Manuscript Review:
CHF 500 and the opportunity to publish a paper free of charge in Antioxidants in 2021
Dr. C. Henrique Alves
Retinal Dysfunction and Neuroinflammation Lab, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Interests: microglia; retina; RPE; neurodegeneration; inflammation; CRB1; gene therapy; retinal organoids; neurodevelopment; IL-23; IL-17; mitochondria
Prof. Dr. Paweł Kafarski
Department of Bioorganic Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland
Interests: natural products of honey; herbs and mushrooms; antioxidants; medicinal chemistry; food alduteration
Two Recognition Awards for Manuscript Review:
The opportunity to publish a paper free of charge in Antioxidants in 2021
Dr. Ana Čipak Gašparović
Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia
Interests: oxidative stress; antioxidative defense; lipid peroxidation; reactive oxygen species (ROS); cancer; cancer stem cells; aquaporins
Prof. Dr. Francisco Solano
Department of Biochemistry, Molecular Biology and Immunology, University of Murcia, Murcia, Spain
Interests: tyrosinase and melanogenesis proteins; melanin pigmentation; photoprotection and other melanin functions; polyphenols as antioxidants; oxidative stress and ROS; skin-lightening agents; ocular; melanin; melanin as polymeric biomaterial; bacterial and fungal melanins; catecholamines; polyamines and amino acid metabolism
Kind regards,
Prof. Dr. Stanley Omaye
Editor-in-Chief, Antioxidants
https://www.mdpi.com/journal/antioxidants/awards
We discuss the role of PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. With a particular focus on its role in mitochondrial dysfunction in disorders such as amyotrophic lateral sclerosis (ALS), Alzheimer ́s, Huntington ́s and Parkinson ́s diseases, as well as eye diseases such as age-related macular degeneration (AMD) and glaucoma.
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-020-01062-w#Ack1
Oxidative stress, neurodegeneration and neuroinflammation are interrelated factors in the aetiology of several brain and retinal degenerative disorders, such as Alzheimer’s and Parkinson´s disease, retinitis pigmentosa, age-related macular degeneration and glaucoma. Oxidative stress results from the imbalance between the production and consumption of reactive oxygen species (ROS). This shift in redox homeostasis can initiate the synthesis and release of pro-inflammatory mediators and the infiltration of immune cells that can further potentiate oxidative stress. These cyclical processes, when uncontrolled, contribute to neuronal cell loss and severe tissue damage.
We invite you to submit your latest research findings or a review article to this Special Issue, “Oxidative Stress in Neurodegeneration and Neuroinflammation”. We aim to gather the latest research about the role of oxidative stress in neurodegeneration and neuroinflammation. We welcome submissions concerning all research models (e.g., in vitro, iPSC-derived cells, organoids, animal models), focusing on all the different nervous system tissues and cell types (e.g., retina, brain, spinal cord, neurons, microglia, astrocytes) and using all types of molecular and cellular approaches that contribute to unraveling and clarifying the pathophysiology and the molecular mechanisms related to neurodegenerative disorders.
https://www.mdpi.com/journal/antioxidants/special_issues/Oxidative_Stress_Neurodegeneration
Author/s | Quinn PM, Buck TM, Mulder AA, Ohonin C, Alves CH, Vos RM, Bialecka M, van Herwaarden T, van Dijk EHC, Talib M, Freund C, Mikkers HMM, Hoeben RC, Goumans MJ, Boon CJF, Koster AJ, Chuva de Sousa Lopes SM, Jost CR, Wijnholds J |
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Journal | Stem Cell Reports, 2019 May 14;12(5):906-919 |
Comment | Manuscript describes a retinal phenotype in cultured human CRB1 patient iPSC-derived retinal organoids as previously detected in vivo in mice lacking retinal CRB1 or CRB2. |
Keywords: Crumbs homologue-1; Leber congenital amaurosis; Microglia; Retina; Retinal inflammation; Retinitis pigmentosa.
We have a new toy in the lab!
The optomotor response (OMR) is a reflex used to assess visual function. The PhenoSys qOMR (quantitative optomotor response) is a unique system that automatically measures the OMR with minimal experimenter effort. It uses a virtual stimulation cylinder that continuously aligns with the animal´s head position. Based on real-time head tracking, quantitative OMR measurements run fully automatically and objectively.
More info at:
https://www.phenosys.com/innovations/qomr/
For the first time, we demonstrate loss of functional vision in a mouse model for CRB1-retinitis pigmentosa.
@Vicentine Coast, Portugal, together with Bike&Beer BTT team (30-7-2019)
Picture by CH Alves