We discuss the role of PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. With a particular focus on its role in mitochondrial dysfunction in disorders such as amyotrophic lateral sclerosis (ALS), Alzheimer ́s, Huntington ́s and Parkinson ́s diseases, as well as eye diseases such as age-related macular degeneration (AMD) and glaucoma.
|Author/s||Quinn PM, Buck TM, Mulder AA, Ohonin C, Alves CH, Vos RM, Bialecka M, van Herwaarden T, van Dijk EHC, Talib M, Freund C, Mikkers HMM, Hoeben RC, Goumans MJ, Boon CJF, Koster AJ, Chuva de Sousa Lopes SM, Jost CR, Wijnholds J|
|Journal||Stem Cell Reports, 2019 May 14;12(5):906-919|
|Comment||Manuscript describes a retinal phenotype in cultured human CRB1 patient iPSC-derived retinal organoids as previously detected in vivo in mice lacking retinal CRB1 or CRB2.|
Keywords: Crumbs homologue-1; Leber congenital amaurosis; Microglia; Retina; Retinal inflammation; Retinitis pigmentosa.
We have a new toy in the lab!
The optomotor response (OMR) is a reflex used to assess visual function. The PhenoSys qOMR (quantitative optomotor response) is a unique system that automatically measures the OMR with minimal experimenter effort. It uses a virtual stimulation cylinder that continuously aligns with the animal´s head position. Based on real-time head tracking, quantitative OMR measurements run fully automatically and objectively.
More info at:
For the first time, we demonstrate loss of functional vision in a mouse model for CRB1-retinitis pigmentosa.
@Vicentine Coast, Portugal, together with Bike&Beer BTT team (30-7-2019)
Picture by CH Alves